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Complement is activated by IgG hexamers assembled at the cell surface

BDNF = brain-derived neurotrophic factor, TrkB = tropomyosin receptor kinase B, HGF = hepatocyte growth factor, c-met = c mesenchymal-epithelial transition factor

Once inside the cell, the complex interacts with intracellular copper-responsive pathways which is what enables the downstream gene-modulation effects to translate from topical application into measurable dermal changes

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HGH also has direct effects on metabolism, promoting the breakdown of fats (lipolysis) and influencing how the body uses glucose